Meeting the Therapeutic Challenges of Emergent and Rare Invasive Fungal Diseases Through Novel Clinical Trial Designs

Introduction (Article introduction authored by ICU Editorial Team) Treatments for rare and emerging invasive fungal diseases (IFDs) are urgently needed. Diseases such as mucormycosis, hyalohyphomycosis, and phaeohyphomycosis occur less frequently…

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New Antibiotics for the Treatment of Nosocomial Central Nervous System Infections

Introduction (Article introduction authored by ICU Editorial Team) Nosocomial CNS infections with carbapenem- and colistin-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria present a growing therapeutic challenge. This review examines the pharmacokinetics,…

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Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician

Introduction In-hospital morbidity and mortality continue to be significantly impacted by invasive candidiasis (IC), a condition caused by the yeast pathogen Candida. The emergence of multi-resistant Candida species, including Candida…

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Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

Introduction Fungal infections are a growing threat to global public health, with some species causing life-threatening illnesses. Immunocompromised patients are at higher risk, and systemic fungal infections can be fatal…

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New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review

Introduction One of the most dangerous organisms that cause major hospital acquired infections is P. aeruginosa. It is naturally resistant to many antimicrobial treatments, and the management of such infections…

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