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Read more about the article New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review
Drug Updates

New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review

Introduction One of the most dangerous organisms that cause major hospital acquired infections is P. aeruginosa. It is naturally resistant to many antimicrobial treatments, and the management of such infections…

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January 9, 2023
Read more about the article RNA-based therapeutics to treat human fungal infections
Drug Updates

RNA-based therapeutics to treat human fungal infections

Background Fungal infections are a major problem affecting over one billion people annually. Emerging pathogens and increasing resistance rates are complicating the situation, while new therapeutic options remain slow to…

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August 23, 2022
Read more about the article Isavuconazole and Liposomal Amphotericin B as Successful Combination Therapy of Refractory Invasive Candidiasis in a Liver Transplant Recipient: A Case Report and Literature Review
Drug Updates

Isavuconazole and Liposomal Amphotericin B as Successful Combination Therapy of Refractory Invasive Candidiasis in a Liver Transplant Recipient: A Case Report and Literature Review

Introduction The treatment of invasive fungal infections in liver transplant recipients is difficult because they are linked to increased morbidity and mortality. Despite a lack of clinical evidence, antifungal combination…

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July 12, 2022
Read more about the article Interaction between posaconazole & flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole & possible undertreatment of invasive aspergillosis: case report
Drug Updates

Interaction between posaconazole & flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole & possible undertreatment of invasive aspergillosis: case report

Introduction Triazole antifungals like voriconazole, posaconazole, and isavuconazole are used to treat invasive fungal infections like pulmonary aspergillosis. Triazoles inhibit cytochrome P450 enzymes (CYP450) and cause fungal cell death by…

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June 6, 2022
Read more about the article Real-World Use of Isavuconazole as Primary Therapy for Invasive Fungal Infections in High-Risk Patients with Hematologic Malignancy or Stem Cell Transplant
Drug Updates

Real-World Use of Isavuconazole as Primary Therapy for Invasive Fungal Infections in High-Risk Patients with Hematologic Malignancy or Stem Cell Transplant

Introduction Despite advancements in antifungal therapy over the last two decades, invasive fungal infections (IFIs) continue to be a major cause of morbidity and mortality among immunocompromised patients, particularly if…

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March 17, 2022
Read more about the article Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents
Drug Updates

Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents

Introduction Heme-containing peroxidases are widely distributed in the animal and plant kingdoms and play an important role in host defense by generating potent oxidants. Myeloperoxidase (MPO), the prototype of heme-containing…

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February 11, 2022
Read more about the article An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria
Drug Updates

An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

Introduction Gram-negative bacteria cause two-thirds of infections in intensive care units (ICUs), and antibiotic resistance among these bacteria is a serious issue. Several multidrug-resistant Gram-negative bacteria, including carbapenem-resistant Acinetobacter baumannii,…

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January 4, 2022
Read more about the article Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections
Drug Updates

Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections

Introduction Cryptococcus neoformans is a life-threatening invasive fungal disease. It is more than merely a multi-organ infection; the fungus' intracellular survival and extracellular proliferation play essential roles in the pathophysiology…

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November 26, 2021
Read more about the article Ibrexafungerp, a Novel Oral Triterpenoid Antifungal in Development: Overview of Antifungal Activity Against Candida glabrata
Drug Updates

Ibrexafungerp, a Novel Oral Triterpenoid Antifungal in Development: Overview of Antifungal Activity Against Candida glabrata

Introduction Candida glabrata is a new Candida species that causes infections ranging from minor to life-threatening systemic illness. Echinocandins and azoles are commonly employed as first-line therapy to treat C.…

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September 13, 2021
Read more about the article Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections
Drug Updates

Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections

Background In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective…

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August 17, 2021
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  • New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review
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  • When to change treatment of acute invasive aspergillosis: an expert viewpoint

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