Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy: A narrative review

Introduction Effective treatment of sepsis demands not only the prompt administration of appropriate antimicrobials but also precise dosing to enhance patient survival. Adequate dosing ensures therapeutic drug concentrations at the…

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Invasive fungal infections in critically ill children: epidemiology, risk factors and antifungal drugs

Introduction Invasive fungal infections (IFIs) pose a significant threat to critically ill children, particularly those with compromised immune systems. Among the most prevalent fungal pathogens are species of Candida, Aspergillus,…

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Risk factors and mortality rates of carbapenem-resistant Gram-negative bacterial infections in intensive care units

Introduction (Article introduction authored by ICU Editorial Team) In recent years, the prevalence of hospital-acquired infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB) has increased globally, posing significant threats to patient…

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Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis

Introduction (Article introduction authored by ICU Editorial Team) The utilization of corticosteroids in the management of sepsis and septic shock has remained contentious despite extensive examination through randomized controlled trials…

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Role of nebulized colistin as a substitutive strategy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective cohort study

Introduction Nosocomial pneumonia caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) is a growing concern worldwide due to limited treatment options and poor prognosis. VAP-prevention strategies have recently been grouped together into…

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Aerosolized Antibiotics to Manage Ventilator-Associated Infections: A Comprehensive Review

Introduction Critically ill patients on ventilators are prone to lower respiratory tract infections, ranging from tracheal tube colonization to ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). VAP is associated with…

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A multisite evaluation of antifungal use in critical care: implications for antifungal stewardship

Introduction ICUs are settings of high antifungal consumption. Excessive antifungal use may cause individual and collective harm due to treatment-related adverse effects, drug–drug interactions and the selection of drug-resistant fungi,…

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