Role of liposomal amphotericin B in intensive care unit: an expert opinion paper

Introduction Invasive fungal infections (IFI) are life-threatening in ICU patients, with rising incidence and persistently high mortality. The increase is linked to complex care needs, immunocompromised states, comorbidities, broad-spectrum antibiotic…

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Current role of ceftobiprole in the treatment of hospital acquired and community acquired pneumonia: expert opinion based on literature and real-life experiences

Introduction (Article introduction authored by INCA Editorial Team) Bacterial pneumonia remains a global health challenge with high morbidity and mortality, particularly in vulnerable populations. Community-acquired pneumonia (CAP) and hospital-acquired pneumonia…

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Guidelines for the use of lung ultrasound to optimise the management of neonatal respiratory distress: international expert consensus

Introduction Respiratory distress is the leading cause of NICU admissions. Rapid diagnosis and appropriate treatment are vital for improving outcomes. Mechanical ventilation (MV) is a key therapy but carries risks…

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Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM

Introduction Candida species are a major cause of hospital-acquired fungal infections, leading to significant illness and death, especially in critically ill or immunocompromised patients. While mucocutaneous forms like oral thrush…

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Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline

Introduction The American Thoracic Society, CDC, European Respiratory Society, and IDSA have updated TB treatment guidelines based on recent clinical trial data. In settings with access to advanced diagnostics, new…

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The Surgical Infection Society Guidelines on the Management of Intra-Abdominal Infection

Introduction Intra-abdominal infections (IAIs) are a significant, often life-threatening condition affecting millions of patients annually, with treatment responsibility typically distributed across various healthcare providers, including surgeons, infectious disease specialists, and…

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Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM

Introduction Invasive fungal diseases (IFD) pose significant morbidity and mortality risks, particularly among immunocompromised patients, but they can also affect non-neutropenic, critically ill adults in the ICU who lack classical…

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Diagnostic limitations and challenges in current clinical guidelines and potential application of metagenomic sequencing to manage pulmonary invasive fungal infections in patients with haematological malignancies

Introduction (Article introduction authored by ICU Editorial Team) Pulmonary invasive fungal infections (pIFI) disproportionately affect patients with hematological malignancies (HM), primarily due to their underlying disease and intensive chemotherapy-induced neutropenia.…

Continue ReadingDiagnostic limitations and challenges in current clinical guidelines and potential application of metagenomic sequencing to manage pulmonary invasive fungal infections in patients with haematological malignancies