The Surgical Infection Society Guidelines on the Management of Intra-Abdominal Infection

Introduction Intra-abdominal infections (IAIs) are a significant, often life-threatening condition affecting millions of patients annually, with treatment responsibility typically distributed across various healthcare providers, including surgeons, infectious disease specialists, and…

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Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM

Introduction Invasive fungal diseases (IFD) pose significant morbidity and mortality risks, particularly among immunocompromised patients, but they can also affect non-neutropenic, critically ill adults in the ICU who lack classical…

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Diagnostic limitations and challenges in current clinical guidelines and potential application of metagenomic sequencing to manage pulmonary invasive fungal infections in patients with haematological malignancies

Introduction (Article introduction authored by ICU Editorial Team) Pulmonary invasive fungal infections (pIFI) disproportionately affect patients with hematological malignancies (HM), primarily due to their underlying disease and intensive chemotherapy-induced neutropenia.…

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Clinical recommendations for the inpatient management of lower respiratory tract infections in children and adolescents with severe neurological impairment

Introduction (Article introduction authored by ICU Editorial Team) Children and adolescents with severe neurological impairment (SNI) face complex medical challenges, often experiencing severe and recurrent lower respiratory tract infections (LRTIs).…

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Management of Bacterial and Fungal Infections in the ICU: Diagnosis, Treatment, and Prevention Recommendations

Introduction (Article introduction authored by ICU Editorial Team) Bacterial and fungal infections are prevalent among intensive care unit (ICU) patients, with up to 50% diagnosed at any given time. These…

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Extracorporeal blood purification therapies for sepsis-associated acute kidney injury in critically ill patients: expert opinion from the SIAARTI-SIN joint commission

Introduction Sepsis-Associated Acute Kidney Injury (SA-AKI) is a critical condition with high morbidity and mortality in intensive care unit patients. Extracorporeal blood purification therapies have been developed for managing sepsis…

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Ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam activities against multidrug-resistant Enterobacterales from United States Medical Centers (2018–2022)

Introduction Treatment options for infections caused by multidrug- resistant (MDR) Enterobacterales are limited and these infections are associated with high clinical failure and mortality rates, especially in vulnerable patients. In…

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