Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM

Introduction Invasive fungal diseases (IFD) pose significant morbidity and mortality risks, particularly among immunocompromised patients, but they can also affect non-neutropenic, critically ill adults in the ICU who lack classical…

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Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy: A narrative review

Introduction Effective treatment of sepsis demands not only the prompt administration of appropriate antimicrobials but also precise dosing to enhance patient survival. Adequate dosing ensures therapeutic drug concentrations at the…

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Harnessing of Artificial Intelligence for the Diagnosis and Prevention of Hospital-Acquired Infections: A Systematic Review

Introduction Healthcare-associated infections (HAIs) are a leading global public health concern, representing the most common adverse events in healthcare. Effective surveillance is crucial for HAI prevention and control, but traditional…

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Invasive fungal infections in critically ill children: epidemiology, risk factors and antifungal drugs

Introduction Invasive fungal infections (IFIs) pose a significant threat to critically ill children, particularly those with compromised immune systems. Among the most prevalent fungal pathogens are species of Candida, Aspergillus,…

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Diagnostic limitations and challenges in current clinical guidelines and potential application of metagenomic sequencing to manage pulmonary invasive fungal infections in patients with haematological malignancies

Introduction (Article introduction authored by ICU Editorial Team) Pulmonary invasive fungal infections (pIFI) disproportionately affect patients with hematological malignancies (HM), primarily due to their underlying disease and intensive chemotherapy-induced neutropenia.…

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Lung ultrasound and supine chest X-ray use in modern adult intensive care: mapping 30 years of advancement (1993–2023)

Introduction (Article introduction authored by ICU Editorial Team) In critically ill patients with acute respiratory failure, thoracic imaging plays a crucial role in evaluating disease nature, extent, and progression, guiding…

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Meeting the Therapeutic Challenges of Emergent and Rare Invasive Fungal Diseases Through Novel Clinical Trial Designs

Introduction (Article introduction authored by ICU Editorial Team) Treatments for rare and emerging invasive fungal diseases (IFDs) are urgently needed. Diseases such as mucormycosis, hyalohyphomycosis, and phaeohyphomycosis occur less frequently…

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