Introduction (Article introduction authored by ICU Editorial Team) Nosocomial CNS infections with carbapenem- and colistin-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria present a growing therapeutic challenge. This review examines the pharmacokinetics,…
Introduction (Article introduction authored by ICU Editorial Team) Invasive candidiasis poses a growing global health threat, with rising incidence and high mortality rates despite limited treatment options. Antifungal resistance is…
Introduction (Article introduction authored by ICU Editorial Team) This study retrospectively analyzed the use of Ceftobiprole (CBP), an anti-MRSA cephalosporin, in treating severe infections in critically ill patients with multiple…
Introduction (Article introduction authored by ICU Editorial Team) Invasive fungal diseases (IFDs) pose a significant global health challenge, with over 300 million severe cases and 1.5 million deaths annually. The…
Introduction In-hospital morbidity and mortality continue to be significantly impacted by invasive candidiasis (IC), a condition caused by the yeast pathogen Candida. The emergence of multi-resistant Candida species, including Candida…
Introduction Fungal infections are a growing threat to global public health, with some species causing life-threatening illnesses. Immunocompromised patients are at higher risk, and systemic fungal infections can be fatal…
Introduction One of the most dangerous organisms that cause major hospital acquired infections is P. aeruginosa. It is naturally resistant to many antimicrobial treatments, and the management of such infections…
Background Fungal infections are a major problem affecting over one billion people annually. Emerging pathogens and increasing resistance rates are complicating the situation, while new therapeutic options remain slow to…
Introduction The treatment of invasive fungal infections in liver transplant recipients is difficult because they are linked to increased morbidity and mortality. Despite a lack of clinical evidence, antifungal combination…
Introduction Triazole antifungals like voriconazole, posaconazole, and isavuconazole are used to treat invasive fungal infections like pulmonary aspergillosis. Triazoles inhibit cytochrome P450 enzymes (CYP450) and cause fungal cell death by…