Introduction Direct damage to airway epithelium and immune dysregulation in severe viral pneumonia along with treatment with immunosuppressive agents is known to cause increased susceptibility to fungal superinfections, such as…
Introduction In patients with underlying chronic lung disease, the prevalence of fungal infection is rising. The environmental mould Aspergillus fumigatus, as well as other filamentous fungi, are primarily responsible for…
Introduction Infections caused by fungi can be important causes of morbidity and mortality in certain patient populations, including those who are highly immunocompromised or critically ill. Invasive mycoses can be…
Introduction This review highlights emerging fungal infections, including newly described species, such as Candida auris, and those that having undergone taxonomic classification and were previously known by other names, including…
Introduction While many antimicrobial classes and compounds are potent in vitro, they may be accompanied with excessive toxicity or poor pharmacokinetics, limiting their clinical value in specific situations. As a…
Introduction Over the past 20 years or so, invasive fungal diseases (IFDs) have become one of the main causes of death in hematological patients treated with high-intensity chemotherapy and/or a…
Introduction Voriconazole is one of the first-line therapies for invasive pulmonary aspergillosis. Many factors, such as drug-drug interactions (DDIs), erratic absorption, and continuous renal replacement therapy (CRRT), influence voriconazole exposure,…
Aim To evaluate the pharmacokinetics of colistimethate sodium and colistin in critically ill patients and correlate with clinical efficacy and renal function. Materials and Methods This prospective observational study was…
Background De-escalation of empirical antimicrobial therapy, a key component of antibiotic stewardship, is considered difficult in ICUs with high rates of antimicrobial resistance. Objectives To assess the feasibility and the…
Background The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk of ICU-acquired pneumonia. Methods This retrospective multicentre cohort study comprised all consecutive patients…