Introduction Leptospiros is thought to be the most widespread zoonosis in the world. A systematic review estimated that there are more than one million cases worldwide, with nearly 60 000…
Introduction Sepsis is a life-threatening condition, and fungal pathogens are an increasingly important cause, especially in high-risk groups. During COVID-19, fungal co-infections gained significant attention due to their high morbidity…
Introduction Sepsis is a critical medical emergency caused by an uncontrolled immune response to infection, resulting in organ dysfunction. It continues to be a major global health challenge with high…
Introduction Antimicrobial resistance (AMR) is a major global health threat. According to the CDC (2019), over 2.8 million antibiotic-resistant infections and 35,000 deaths occur annually in the U.S., rising to…
Introduction This post-hoc analysis of a multinational ICU study assessed and compared the clinical profiles, microbiological findings, and outcomes of immunosuppressed versus non-immunosuppressed patients with nosocomial lower respiratory tract infections…
Introduction Multidrug-resistant organisms (MDROs) are bacteria resistant to at least one antibiotic in three or more antimicrobial categories, posing a serious global health threat. Antimicrobial resistance (AMR) leads to increased…
Introduction (Article introduction authored by INCA Editorial Team) Sepsis, a life-threatening condition caused by a dysregulated immune response to infection, remains a major global health challenge. Its high heterogeneity complicates…
Introduction Effective treatment of sepsis demands not only the prompt administration of appropriate antimicrobials but also precise dosing to enhance patient survival. Adequate dosing ensures therapeutic drug concentrations at the…
Introduction Invasive fungal infections (IFIs) pose a significant threat to critically ill children, particularly those with compromised immune systems. Among the most prevalent fungal pathogens are species of Candida, Aspergillus,…
Introduction (Article introduction authored by ICU Editorial Team) Invasive fungal infections, particularly those caused by moulds, pose significant morbidity and mortality risks. Limited antifungal classes suffer from toxicities and increasing…