Introduction The intensive care unit (ICU) is a fast-paced, high-risk environment where human lives depend on rapid, precise decisions. Despite technological advancements, human and system-related errors—especially medication errors—remain a major…
Introduction Candida species are a major cause of hospital-acquired fungal infections, leading to significant illness and death, especially in critically ill or immunocompromised patients. While mucocutaneous forms like oral thrush…
Introduction The rise of antimicrobial resistance, especially among Gram-negative bacteria, has led to the development of new β-lactam/β-lactamase inhibitor (BL/BLI) combinations. Recently approved agents—cefepime/enmetazobactam, aztreonam/avibactam, and sulbactam/durlobactam—target resistant pathogens like…
Introduction This post-hoc analysis of a multinational ICU study assessed and compared the clinical profiles, microbiological findings, and outcomes of immunosuppressed versus non-immunosuppressed patients with nosocomial lower respiratory tract infections…
Introduction The concept of “time is spine” underscores the importance of early (within 24 hours) or ultra-early (within 12 hours) surgical decompression following spinal cord injury (SCI) to improve neurological…
Introduction The American Thoracic Society, CDC, European Respiratory Society, and IDSA have updated TB treatment guidelines based on recent clinical trial data. In settings with access to advanced diagnostics, new…
Introduction Recurrent urinary tract infections (UTIs) are defined as 2 infections in 6 months or 3 in 12 months, with at least 2 weeks of symptom-free interval. Symptoms include frequent…
Introduction Nosocomial lower respiratory tract infections (nLRTIs), including HAP and VAP, remain a major healthcare burden due to high mortality and cost. Traditional culture methods are slow and often inconclusive.…
Introduction Multidrug-resistant organisms (MDROs) are bacteria resistant to at least one antibiotic in three or more antimicrobial categories, posing a serious global health threat. Antimicrobial resistance (AMR) leads to increased…
Introduction Candidemia and invasive candidiasis continue to pose high morbidity and mortality risks, especially in healthcare settings. With rising fluconazole resistance and limitations of current echinocandin treatments such as prolonged…