Role of nebulized colistin as a substitutive strategy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective cohort study

Introduction Nosocomial pneumonia caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) is a growing concern worldwide due to limited treatment options and poor prognosis. VAP-prevention strategies have recently been grouped together into…

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Aerosolized Antibiotics to Manage Ventilator-Associated Infections: A Comprehensive Review

Introduction Critically ill patients on ventilators are prone to lower respiratory tract infections, ranging from tracheal tube colonization to ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). VAP is associated with…

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A multisite evaluation of antifungal use in critical care: implications for antifungal stewardship

Introduction ICUs are settings of high antifungal consumption. Excessive antifungal use may cause individual and collective harm due to treatment-related adverse effects, drug–drug interactions and the selection of drug-resistant fungi,…

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Ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam activities against multidrug-resistant Enterobacterales from United States Medical Centers (2018–2022)

Introduction Treatment options for infections caused by multidrug- resistant (MDR) Enterobacterales are limited and these infections are associated with high clinical failure and mortality rates, especially in vulnerable patients. In…

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The use of smart environments and robots for infection prevention control: A systematic literature review

Introduction Infection prevention and control (IPC) is essential to prevent nosocomial infections. This manuscript aims at investigating the current use and role of robots and smart environments on IPC systems…

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Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician

Introduction In-hospital morbidity and mortality continue to be significantly impacted by invasive candidiasis (IC), a condition caused by the yeast pathogen Candida. The emergence of multi-resistant Candida species, including Candida…

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Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

Introduction Fungal infections are a growing threat to global public health, with some species causing life-threatening illnesses. Immunocompromised patients are at higher risk, and systemic fungal infections can be fatal…

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Robots and Intelligent Medical Devices in the Intensive Care Unit: Vision, State of the Art and Economic Analysis

Introduction Robotics is frequently regarded as a crucial enabling technology for tomorrow's society. This study looks at how robotics and intelligent medical devices (IMD) are used in intensive care. The…

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Intensive Care Unit Physicians’ Perspectives on Artificial Intelligence–Based Clinical Decision Support Tools: Preimplementation Survey Study

Introduction Artificial intelligence–based clinical decision support (AI-CDS) tools to enhance personalized medicine is on the rise. In the ICU, complex and high-stakes decisions are made that might benefit from data-driven…

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